Y.Iwadare
抗うつ薬による自殺関連事象は予測できるか?
Patients On Antidepressants Can Be Tested For Signs Of Suicidal Thoughts
http://www.medicalnewstoday.com/articles/185074.php
  • a small subset of individuals taking these drugs can actually experience a worsening of mood, and even thoughts of suicide.
  • Now, UCLA researchers have developed a non-invasive biomarker, or indicator, that may serve as a type of early warning system.
  • report that by using quantitative electroencephalographic (QEEG), a non-invasive measurement of electrical activity in the brain, they were able to observe a sharp reduction of activity in a specific brain region in individuals who proved susceptible to thoughts of suicide - within 48 hours of the start of treatment.
  • shown that between 8 and 14 percent of depressed patients develop thoughts of suicide while taking the most common forms of depression drugs, known as selective serotonin reuptake inhibitors (SSRI).
  • This study suggests, for the first time, a link between worsening suicidality and specific changes in brain function while on these medications.
  • The drop occurred in the midline and right-frontal sections of the brain, areas known to control emotions.
  • Importantly, changes in this biomarker did not predict worsening suicidal thoughts in the placebo-treated subjects, so the results suggest 
    that the biomarker specifically detected medication-related worsening only.”
QEEGとは?? NIRSみたいなものなのか? 抗うつ薬を服用して48時間以内に行えば、自殺への危険性を予測できるなんて そんなことって本当にあるのかな??
ちょっと信じられない。
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独立行政法人国立国際医療研究センター国府台病院
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